Intrathecal morphine resulted to be 7.5 times more potent than ip morphine in the writhing test, 55.6 times in the tail flick test and 1.7 times in phase II of the orofacial formalin test however, in phase I of the same test ip was 1.2 times more potent than it morphine. This study, performed in mice using isobolographic analysis, evaluated the type of interaction in intraperitoneal ( ip) or intrathecal (it) coadministration of codeine and morphine, in three nociceptive behavioral models. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. The combination of two analgesic agents offers advantages in pain treatment. Miranda, Hugo F Noriega, Viviana Zepeda, Ramiro J Sierralta, Fernando Prieto, Juan C Systemic synergism between codeine and morphine in three pain models in mice.
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